Catalytic and Sustainable Amide Bond Formation using a DABCO/Dichlorotriazine System

Amides are one of the most important functional groups in organic chemistry and play essential roles both pharmaceutical industry life sciences. However, due to natural reactivity carboxylic acids amines, their direct coupling is challenging often leads reactions that not atom-economic produce large amounts non-recoverable by-products. Despite impressive number reagents available, sustainable methods for amide bond formation still needed. To address this challenge, a new catalytic approach preparation amides from amines reported here. This method combines organocatalysis with substoichiometric amount activating agent under mild conditions (open air, room temperature, green solvents). was applied good efficiency on wide range substrates, without epimerization chiral stereocenters SPPS.